陈烨，理学博士，教授、博士生导师。长期围绕“细胞与微环境组分间的相互调控”开展基础和临床转化研究工作，相关成果发表在 Journal of Clinical Investigation、BLOOD、Advanced Science、 Signal Transduction and Targeted Therapy、Protein & Cell 、Journal of Immunology 等主流学术期刊。实验室目前主要研究方向包括干细胞分化调控与组织再生、免疫细胞分化和发育、免疫稳态及调节等。

教育和工作经历:

2000/09-2004/07  浙江大学 生命科学学院 生物科学专业     学士

2004/09-2009/07  浙江大学 生命科学学院 细胞生物学专业   博士 （导师：邵建忠教授） 

2009/09-2013/06  美国 MD. Anderson Cancer Center, Department of Stem Cell Transplantation & Cellular Therapy/Department of Leukemia  博士后（research fellow）（导师：Michael Andreeff, M.D.,Ph.D.） 

2013/07-2019/12  浙江大学 生命科学学院、医学院  研究员、博士生导师

2019/12-迄今       浙江大学  医学院 、生命科学学院 教授、博士生导师

• 1.        国家自然科学基金项目：(32473191)，2025.01-2028.12

• 2.        浙江省重大：2024.01-2028.12

• 3.        浙江省领雁：(2024C03230)，2024.01-2026.12

• 4.        浙江省自然科学基金重点项目：(Z23C070002)，2023.01-2025.12

• 5.        国家重点研发计划：(2020YFA0113003)，2020.10-2025.12

• 6.        国家重点研发计划：(2018YFC1004803)，2018.01-2022.12

• 7.        国家自然科学基金项目：(31671305)，2017.01-2020.12

• 8.        国家重点基础研究发展计划：(2014CB541703)， 2016.01-2018.12

• 9.        浙江省杰出青年基金： (R15H080001)，2015.01-2018.12

• 10.    国家自然科学基金项目：(81470685)，2015.01-2018.12

• 11.    国家重点基础研究发展计划：(2014CB541702)， 2014.01-2015.12

• 12.    企事业单位委托研发项目：若干

• Ji JF, Zhang N, Hu CB, Fan DD, Huang X, Lin AF, Chen Y*, Xiang L*, Shao JZ*. Mef2d regulates mutually exclusive expression of IgZ and IgM isotypes through epigenetic modulation in a zebrafish model. Fundamental Research. 2024-05. DOI: 10.1016/j.fmre.2024.04.019

• Hu CB, Zhang N, Hong Y, Tie R, Fan DD, Lin AF, Chen Y*, Xiang L*, Shao JZ*. Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity. eLife. 2024;13:RP92424.  https://doi.org/10.7554/eLife.92424.1

• Hu CB, Huang C, Wang J, Hong Y, Fan DD, Chen Y, Lin AF, Xiang LX, Shao JZ. PD-L1/BTLA Checkpoint Axis Exploited for Bacterial Immune Escape by Restraining CD8+ T Cell-Initiated Adaptive Immunity in Zebrafish. J Immunol. 2023 Sep 1;211(5):816-835.

• Zhao Q, Chang H, Zheng J, Li P, Ye L, Pan R, Li D, Shao JZ, Zhao R C, Chen Y*. A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype. Signal Transduction and Targeted Therapy. 2023; 8 (1): pp.86.

• Ying H, Shen C, Pan R, Li X, Chen Y*. Strategy insight: Mechanical properties of biomaterials' influence on hydrogel-mesenchymal stromal cell combination for osteoarthritis therapy. Front Pharmacol. 2023 Apr 19;14:1152612.

• Bian Q, Jiao X, Chen Y, Yu H, Ye L. Hierarchical dynamic regulation of Saccharomyces cerevisiae for enhanced lutein biosynthesis. Biotechnol Bioeng. 2023 Feb;120(2):536-552.

• Zhao Q, Zhang L, He Q, Chang H, Wang Z, Cao H, Zhou Y, Pan R, Chen Y*. Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways. J Zhejiang Univ Sci B. 2023 Jan 15;24(1):50-63.

• Shen S, Li Y, Jin M, Fan D, Pan R, Lin A, Chen Y*, Xiang L*, Zhao R C*, Shao JZ*. CD4 + CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver. Aging and Disease. 2022 Dec 1;13(6):1919-1938.

• Wang Z, Hu X, He Q, Lai J, Pan R, Zheng J, Chen Y*. Establishment and characterization of IPS-OGC-C1: a novel induced pluripotent stem cell line from healthy human ovarian granulosa cells. Hum Cell. 2022 Sep;35(5):1612-1620.

• Zhang L, Zhao Q, Wang Z, Hu X, Pan R, Yang Y, Chen Y*. Acute Myeloid Leukemia Cells Educate Mesenchymal Stromal Cells toward an Adipogenic Differentiation Propensity with Leukemia Promotion Capabilities. Advanced Science. 2022 Mar 20;9(16):2105811.

• Wang Z, Zheng J, Pan R, Chen Y*. Current status and future prospects of patient-derived induced pluripotent stem cells. Hum Cell. 2021 Aug 10. 

• He Q, He X, Xiao Y, Zhao Q, Ye Z, Cui L, Chen Y*, Guan MX*. Tissue-specific expression atlas of murine mitochondrial tRNAs. J Biol Chem. 2021 Jul 13;297(2):100960.

• Ying H, Pan R, Chen Y* . Epigenetic Control of Mesenchymal Stromal Cell Fate Decision, Post-Translational Modifications in Cellular Functions and Diseases, Shibo Ying, IntechOpen. (April 20th 2021; Book chapter)

• He Q, Zhao Q, Li Q, Pan R, Li X, Chen Y*. Mtu1 defects are correlated with reduced osteogenic differentiation, Cell Death & Disease, 2021, 12(1):0-61.

• Ye M, Chen Y*. Zebrafish as an emerging model to study gonad development, Comput Struct Biotechnol J, 2020, 18: 2373-2380.

• Cui L, Zheng J, Zhao Q, Chen JR, Liu H, Peng G, Wu Y, Chen C, He Q, Shi H, Yin S, Friedman R. A, Chen Y*, Guan MX*. Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss, JCI Insight, 2020, 5(23): e136046

• Zhang LW, Cang XH, Chen Y*, Guan MX. In vitro culture of mammalian inner ear hair cells. J Zhejiang Univ Sci B. 2019 Feb.;20(2):170-179.

• Zheng J, Meng WF, Zhang CF, Liu HQ, Yao J, Wang H, Chen Y*, Guan MX. New SNP variants of MARVELD2 (DFNB49) associated with non-syndromic hearing loss in Chinese population. J Zhejiang Univ Sci B. 2019 Feb.;20(2):164-169.

• Fan W, Zheng J, Kong W, Cui L, Aishanjiang M, Yi Q, Wang M, Cang X, Tang X, Chen Y, Mo JQ, Sondheimer N, Ge W, Guan MX. Contribution of a mitochondrial tyrosyl-tRNA synthetase mutation to the phenotypic expression of the deafness-associated tRNASer(UCN) 7511A>G mutation. J Biol Chem. 2019 Dec 13;294(50):19292-19305.

• Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y*, Guan MX*. Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function. Nucleic Acids Res. 2018 Nov 16;46(20):10930-10945.

• Hu X, Mei S, Meng W, Xue S, Jiang L, Yang Y, Hui L, Chen Y*, Guan MX. CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance. Cancer Lett. 2018 Mar 21;425:1-12.

• Chen X, Wang F, Maerhaba A, Li Q, Wang J, Liu X, Zheng J, Chen Y, Guo Y. Novel mitochondrial gene variants in Northwestern Chinese probands with non-syndromic hearing loss by whole mitochondrial genome screening. Gene. 2018 Apr 30;652:59-65.

• Meng W, Xue S, Chen Y*. The role of CXCL12 in tumor microenvironment. Gene. 2018 Jan 30;641:105-110.

• Li Q, Gao Z, Chen Y*, Guan MX. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein Cell. 2017 Jun;8(6):439-445.  

• Gao Z, Chen Y*, Guan MX. Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity. Journal of Otology. 2017 Mar;12(1):1-8.

• Su X, Wang W, Ruan G, Liang M, Zheng J, Chen Y, Wu H, Fahey TJ, Guan M, Teng L. A Comprehensive Characterization of Mitochondrial Genome in Papillary Thyroid Cancer. Int J Mol Sci. 2016 Oct 10;17(10). pii: E1594.

• Chen D, Li F, Yang Q, Tian M, Zhang Z, Zhang Q, Chen Y*, Guan MX. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Int J Biochem Cell Biol. 2016 May 13;77(Pt A):1-9.

• Jiang P, Wang M, Xue L, Xiao Y, Yu J, Wang H, Yao J, Liu H, Peng Y, Liu H, Li H, Chen Y, Guan MX. A hypertension-associated tRNAAla mutation alters the tRNA metabolism and mitochondrial function. Mol Cell Biol. 2016 Jun 29;36(14):1920-30.

• Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M. Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network. Oncotarget. 2016 Apr 12;7(15):20054-67.

• Zhang W, Borthakur G, Gao C, Chen Y, Mu H, Ruvolo V, Nomoto K, Zhao N, Konopleva M, Andreeff M. The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations. Cancer Research, 2016 Mar 15;76(6):1528-37.

• Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, Ji Y, Liang M, Zhao F, Sun Y, Zhang M, Zhou X, Chen Y, Mo J, Huang T, Qu J, Guan MX. The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber’s hereditary optic neuropathy-associated mitochondrial DNA mutation. Human Molecular Genetics, 2016 Feb 1;25(3):584-96.

• Hui L, Chen Y*. Tumor microenvironment: sanctuary of the devil. Cancer Letter, 2015 Nov 1;368(1):7-13.

• Chen C, Chen Y*, Guan MX. A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation. Protein & Cell, 2015 Dec;6(12):862-70.

• Ying Z, Zheng J, Cai Z, Liu L, Dai Y, Yao J, Wang H, Gao Y, Zheng B, Tang X, Zhu Y, Guan MX, Chen Y*. Mitochondrial haplogroup B increases the risk for hearing loss among the Eastern Asian pedigrees carrying 12S rRNA 1555A>G mutation. Protein & Cell, 2015 Nov;6(11):844-8.

• Zheng J, Ying Z, Cai Z, Sun D, He Z, Gao Y, Zhang T, Zhu Y, Chen Y*, Guan MX. GJB2 Mutation Spectrum and Genotype-Phenotype Correlation in 1067 Han Chinese Subjects with Non-Syndromic Hearing Loss. PLoS One. 2015 Jun 4;10(6):e0128691.

• Tang X, Zheng J, Ying Z, Cai Z, Gao Y, He Z, Yu H, Yao J, Yang Y, Wang H, Chen Y, Guan MX. Mitochondrial tRNASer(UCN) variants in 2651 Han Chinese subjects with hearing loss. Mitochondrion. 2015 May 10;23:17-24.

• Yu J, Zheng J, Zhao X, Liu J, Mao Z, Ling Y, Chen D, Chen C, Hui L, Cui L, Chen Y, Jiang P, Guan MX. Aminoglycoside Stress Together with the 12S rRNA 1494C>T Mutation Leads to Mitophagy. PLoS One. 2014 Dec 4;9(12):e114650.

• Zhang W, Gao C, Konopleva M, Chen Y, Jacamo RO, Borthakur G, Cortes JE, Ravandi F, Ramachandran A, Andreeff M. Reversal of Acquired Drug Resistance in FLT3-mutated Acute Myeloid Leukemia Cells via Distinct Drug Combination Strategies. Clin Cancer Res. 2014 May 1;20(9):2363-74.

• Jacamo R, Chen Y, Wang Z, Ma W, Zhang M, Spaeth EL, Wang Y, Battula VL, Mak PY, Schallmoser K, Ruvolo P, Schober WD, Shpall EJ, Nguyen MH, Strunk D, Bueso-Ramos CE, Konoplev S, Davis RE, Konopleva M, Andreeff M. Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kB mediates chemoresistance. BLOOD. 2014 Apr 24;123(17):2691-702.

• Lu H, Kojima K, Battula VL, Korchin B, Shi Y, Chen Y, Spong S, Thomas DA, Kantarjian H, Lock RB, Andreeff M, Konopleva M. Targeting connective tissue growth factor (CTGF) in acute lymphoblastic leukemia preclinical models: anti-CTGF monoclonal antibody attenuates leukemia growth. Ann Hematol. 2014 Mar;93(3):485-492.

• Battula VL, Chen Y, Cabreira Mda G, Ruvolo V, Wang Z, Ma W, Konoplev S, Shpall E, Lyons K, Strunk D, Bueso-Ramos C, Davis RE, Konopleva M, Andreeff M. Connective tissue growth factor regulates adipocyte differentiation of mesenchymal stromal cells and facilitates leukemia bone marrow engraftment. BLOOD. 2013 Jul 18;122(3):357-66.

• Chen Y, Rodrigo Jacamo, Marina Konopleva, Ramiro Garzon, Carlo Croce, Michael Andreeff. CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia. J Clin Invest. 2013 Jun;123(6):2395-407.

• Ling X, Spaeth E, Chen Y, Zhang W, Schober W, Hail N Jr, Konopleva M, Andreeff M.The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo. PLOS ONE. 2013;8(3):e58426.

• Chen Y, Jacamo R, Shi YX, Wang RY, Battula VL, Konoplev S, Strunk D, Hofmann NA, Reinisch A, Konopleva M, Andreeff M. Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment. BLOOD. 2012;119(21):4971-80.

• Kojima K, McQueen T, Chen Y, Jacamo R, Konopleva M, Shinojima N, Shpall E, Huang X, Andreeff M. p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12. BLOOD. 2011;118(16):4431-9.

• Chen Y, Xiang LX, Shao JZ, Pan RL, Wang YX, Dong XJ, Zhang GR. Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver. J Cell Mol Med. 2010;14(6B):1494-508.

• Chen Y, Pan RL, Zhang XL, Shao JZ, Xiang LX, Dong XJ, Zhang GR. Induction of hepatic differentiation of mouse bone marrow stromal stem cells by the histone deacetylase inhibitor VPA. J Cell Mol Med. 2009;13(8B):2582-92.

• Pan RL#, Chen Y#, Xiang LX, Shao JZ, Dong XJ, Zhang GR. Fetal liver-conditioned medium induces hepatic specification from mouse bone marrow mesenchymal stem cells: a novel strategy for hepatic trans-differentiation. Cytotherapy. 2008;10(7):668-75.

• Chen Y, Shao JZ, Xiang LX, Dong XJ, Zhang GR. Mesenchymal stem cells: a promising candidate in regenerative medicine. Int J Biochem Cell Biol. 2008;40(5):815-20.

• Dong XJ, Zhang GR, Zhou QJ, Chen Y, Xiang LX, Shao JZ. Direct hepatic differentiation of mouse embryonic stem cells induced by valproic acid and cytokines. World J Gastroenterol. 2009 Nov 7;15(41):5165-75.

• Chen Y, Dong XJ, Zhang GR, Shao JZ, Xiang LX. In vitro differentiation of mouse bone marrow stromal stem cells into hepatocytes induced by conditioned culture medium of hepatocytes. J Cell Biochem. 2007;102(1):52-63.

• Chen Y, Dong XJ, Zhang GR, Shao JZ, Xiang LX. Transdifferentiation of mouse BM cells into hepatocyte-like cells. Cytotherapy. 2006;8(4):381-9.

• Chen Y, Shao JZ, Xiang LX, Guo J, Zhou QJ, Yao X, Dai LC, Lu YL. Cyclic adenosine 3', 5'-monophosphate induces differentiation of mouse embryonic stem cells into cardiomyocytes. Cell Biol Int. 2006;30(4):301-7.