1978.9-1982.7    北京大学生物学系 本科

1982.8-1983.8    北京大学生物学系 研究生（导师李汝祺教授）

1983.9-1990.7    美国哈佛大学生物化学和分子生物学系 博士研究生（ 导师Mark Ptashne教授）                                        

1989.7-1992.6    哈佛学会（Harvard Society of Fellows）青年会员

1992.7-2017.8    美国辛辛那提大学医学院儿童医院研究中心 助理教授，副教授及教授

2017.9-至今        浙江大学医学院，遗传学研究所 教授

• Ma, J., and Ptashne, M. (1987).  Deletion analysis of GAL4 defines two transcriptional activating segments.  Cell 48, 847-853.  PMID: 3028647

• Ma, J., and Ptashne, M. (1987).  The carboxy terminal 30 amino acids of GAL4 are recognized by GAL80.  Cell 50, 137-142.  PMID: 3297349

• Ma, J., and Ptashne, M. (1987).  A new class of yeast transcriptional activators.  Cell 51, 113-119.  PMID: 3115591

• Ruden, D., Ma, J., and Ptashne, M. (1988).  No strict alignment is required between a transcriptional activator binding site and the "TATA box" of a yeast gene.  Proc. Natl. Acad. Sci. USA 85, 4262-4266.   PMID: 3132708; PMCID: PMC280407

• Ma, J., Przibilla, E., Hu, J., Bogorad, L., and Ptashne, M. (1988).  Yeast activators stimulate plant gene expression.  Nature 334, 631-633.   PMID: 3165494

• Sadowski, I., Ma, J., Triezenberg, S., and Ptashne, M. (1988).  GAL4-VP16 is an unusually potent transcriptional activator.  Nature 335, 563-564.  PMID: 3047590

• Ma, J., and Ptashne, M. (1988). Converting a eukaryotic transcriptional inhibitor into an activator.  Cell 55, 443-446.  PMID: 3180218

• Driever, W., Ma, J., Nusslein-Volhard, C., and Ptashne, M. (1989).  Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences.  Nature 342, 149-154.  PMID: 2509940 

• Ruden, D., Ma, J., Li, Y., Wood, K., and Ptashne, M. (1991).  Generating yeast transcriptional activators containing no yeast protein sequences.  Nature 350, 250-252.  PMID: 2005981

• Dasmahapatra, B., DiDomenico, B., Dwyer, S., Ma, J.,  Sadowski, I., and Schwartz, J. (1992).  A novel genetic system to study a proteolytic enzyme.  Proc. Natl. Acad. Sci. USA 89, 4159-4162.  PMID: 1570342; PMCID: PMC525652

• Ma, J. (1992).  Detecting interactions between eukaryotic proteins in bacteria. Gene Expression 2, 139-146.  PMID: 1633437

• Lehming, N., Thanos, D., Brickman, J., Ma, J.,  Maniatis, M., and Ptashne, M. (1994).  A HMG-like protein that can switch a transcriptional activator to a repressor.  Nature 371, 175-179.  PMID: 8072548

• Ma, X., Yuan, D., Diepold, K., Scarborough, T., and Ma, J. (1996).  The Drosophila morphogenetic protein Bicoid binds DNA cooperatively.  Development 122, 1195-1206.  PMID: 8620846

• Shaw, S. P., Wingfield, J., Dorsey, M. J., and Ma, J.  (1996). Identifying a species-specific region of yeast TFIIB in vivo.  Molecular and Cellular Biology 16, 3651-3657.  PMID: 8668181; PMCID: PMC231360

• Yuan, D., Ma, X., and Ma, J. (1996).  Sequences outside the homeodomain of Bicoid are required for protein-protein interaction. J. Biol. Chem. 271, 21660-21665.  PMID: 8702955

• Shaw, S. P., Carson, D. J., Dorsey, M. J., and Ma, J.  (1997).  Mutational studies of yeast TFIIB in vivo reveal a functional surface important for gene activation. Proc. Natl. Acad. Sci. USA 94, 2427-2432.  PMID: 9122211; PMCID: PMC20104

• Ma, X., Yuan, D., Scarborough, T., and Ma, J. (1999).  Contribution to gene activation by multiple functions of Bicoid. Biochem. J. 338, 447-455.  PMID: 10024522; PMCID: PMC1220072

• Yuan, D., Ma, X., and Ma, J. (1999).  Recognition of multiple patterns of DNA sites by the Drosophila homeodomain protein Bicoid.  J. Biochem. 125, 809-817.  PMID: 10101296

• Zhang, D., Dorsey, M. J., Voth, W. P., Carson, D. J., Zeng, X., Stillman, D. J., and Ma, J. (2000).  Intramolecular interaction of yeast TFIIB in transcriptional Control.  Nucl. Acids Res.  28, 1913-1920.  PMID: 10756191; PMCID: PMC103289

• Dave, V., Zhao, C., Yang, F., Tung, C.-S., and Ma, J. (2000).  Reprogrammable recognition codes in Bicoid homeodomain-DNA interaction.  Mol. Cell. Biol. 20, 7673-7684.  PMID: 11003663; PMCID: PMC86337

• Zhao, C., Dave, V., Yang, F. Scarborough, T., and Ma, J. (2000).  Target selectivity of Bicoid is dependent on non-consensus site recognition and protein-protein interaction. Mol. Cell. Biol. 20, 8112-8123.  PMID: 11027281; PMCID: PMC86421

• Zhao, C., York, A., Yang, F., Forsthoefel, D. J., Dave, V., Fu, D., Zhang, D., Corado, M. S., Small, S., Seeger, M. A., and Ma, J. (2002).  The activity of the Drosophila morphogenetic protein Bicoid is inhibited by a domain located outside its homeodomain.  Development 129, 1669-1680.  PMID: 11923203

• Zhang, D., Carson, D. J., and Ma, J.  (2002).  The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells.  Nucl. Acids Res. 30, 3078-3085.  PMID: 12136090; PMCID: PMC135743

• Zeng, X., Zhang, D, Dorsey, M, and Ma, J. (2003).  Hypomutable regions of yeast TFIIB in a unigenic evolution test represent structural domains.  Gene 309, 49-56.  PMID: 12727357

• Leung, T.C., Bischof, J., Soll, I., Niessing, D., Zhang, D., Ma, J., Jackle, H., and Driever, W.  (2003).  bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish. Development 130, 3639-3649.  PMID: 12835381

• Fu, D., Zhao, C., and Ma, J. (2003).  Enhancer sequences influence the role of the amino terminal domain of Bicoid in transcription. Mol. Cell. Biol. 23, 4439-4448.  PMID: 12808087; PMCID: PMC164838

• Zhao, C., Fu, D., Dave, V., and Ma, J.  (2003).  A composite motif of the Drosophila morphogenetic protein Bicoid critical to transcription control and pattern formation. J. Biol. Chem. 278, 43901-43909.  PMID: 12939280 

• Fu, D., Wen, Y., and Ma, J. (2004).  The co-activator  CREB-binding protein participates in enhancer-dependent activities of Bicoid.  J. Biol. Chem. 279, 48725-48733.  PMID: 15358774

• Chaney, B. A., Clark-Baldwin, K., Dave, V., Ma, J., and Rance, M. (2005).  Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome.  Biochemistry 44, 7497-7511.  PMID: 15895993

• Fu, D., and Ma, J. (2005).  Interplay between positive and negative activities that influence the role of Bicoid in transcription.  Nucl. Acids Res. 33, 3985-3993.  PMID: 16030350; PMCID: PMC1178001

• Baird-Titus, J., Clark-Baldwin, K., Dave, V., Caperelli, C. A., Ma, J., and Rance, M. (2006).  The solution structure of the native K50 Bicoid homeodomain to the consensus TAATCC DNA-binding site.  J. Mol. Biol. 356, 1137-1151.  PMID: 16406070

• Song, Y., He, F., Xie, G., Guo, X., Xu, Y., Chen, Y., Liang, X., Stagljar, I., Egli, D., Ma, J., and Jiao, R. (2007).  CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory.  Dev. Biol. 311, 213-222.  PMID: 17916346

• He, F., Wen, Y., Deng, J., Lin, X., Lu, J., Jiao, R., and Ma, J. (2008).  Probing intrinsic properties of a robust morphogen gradient in Drosophila.  Dev. Cell 15, 558-567.  PMID: 18854140; PMCID: PMC2629455

• Xu, Y., Lei, Z., Huang, H., Dui, W., Ma, J., and Jiao, R. (2009).  dRecQ4 is required for DNA synthesis and essential for cell proliferation in Drosophila.  PLoS One 4(7), e6107.  PMID: 19572017; PMCID: PMC2700968

• Deng, J., Wang, W., Lu, J. L., and Ma, J. (2010).  A two-dimensional simulation model of the Bicoid gradient in Drosophila.  PLoS ONE 5(4), e10275.  PMID: 20422054; PMCID: PMC2858077 

• Chen, Y., Dui, W., Yu, Z., Li, C., Ma, J., and Jiao, R. (2010).  Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo.  Protein & Cell 1(5), 478-490.  PMID: 21203963 

• He, F., Sounders, T., E., Wen, Y., Cheung, D., Jiao, R., Ten Wolde, P. R., Howard, M., and Ma, J. (2010).  Shaping a morphogen gradient for positional precision.  Biophy. J.  99, 697-707.  PMID: 20682246; PMCID: PMC2913175 

• Huang, H., Yu, Z., Zhang, S., Liang, X., Chen, J., Li, C., Ma, J., and Jiao, R. (2010).  Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability.  J. Cell Sci. 123, 2853-2861.  PMID: 20663913 

• He, F., Wen, Y., Cheung, D., Deng, J., Lu, L. J., Jiao, R., and Ma, J. (2010).  Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos.  BMC Dev. Biol. 10, 80.  PMID: 20678215; PMCID: PMC2919471 

• Liu, J. and Ma, J. (2011).  Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.  Nature Cell Biol. 13, 22-29.  PMID: 21170036; PMCID: PMC3074934

• He, F., Ren, J., Wang, W., and Ma, J. (2011).  A multiscale investigation of Bicoid-dependent transcriptional events in Drosophila embryos.  PLoS ONE 6, e19122.  PMID: 21544208 PMCID: PMC3081338 

• Huang, H., Chen, H., Liang, X., Li C., Xue, L., Ma, J., and Jiao, R. (2011).  Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus.  Development 138, 2477-2485.  PMID: 21561986 

• Cheung, D., Miles, C., Kreitman, M., and Ma, J. (2011).  Scaling of the Bicoid morphogen gradient by a volume-dependent production rate.  Development 138, 2741-2749.  PMID: 21613328; PMCID: PMC3109599

• Ren, J., Jegga, A., Zhang, M., Deng, J., Liu, J., Gordon, C. B., Aronow, B. J., Lu, L. J., Zhang, B., and Ma, J. (2011).  A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome.  Human Mol. Genetics 20, 3424-3436.  PMID: 21653638; PMCID: PMC3153307

• He, F., Ren, J., Wang, W., and Ma, J. (2012).  Evaluating the Drosophila Bicoid morphogen gradient system through dissecting the noise in transcriptional bursts.  Bioinformatics 28, 970-975.  PMID: 22302571; PMCID: PMC3315720

• Xie, G., Zhang, H., Du, G., Huang, Q., Liang, X., Ma, J., and Jiao, R.  (2012).  Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila.  PLoS ONE 7: e36362.  PMID: 22558447; PMCID: PMC3340373

• Liu, J. and Ma, J. (2012). Drosophila Bicoid is a substrate of sumoylation and its activator function is subject to inhibition by this post-translational modification.  FEBS Letters 586, 1719-1723.  PMID: 22584054; PMCID: PMC3372618

• Dui, W., Lu, W., Ma, J., and Jiao, R. (2012).  A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Journal of Genetics and Genomics 39, 397-413.  PMID: 22884096

• Dui, W., Wei, B., He, F., Lu, W., Li, C., Liang, X., Ma, J., and Jiao, R. (2013).  The Drosophila F-box protein dSkp2 regulates cell proliferation through targeting Dacapo for degradation.  Mol. Biol. Cell 24, 1676-1687.  PMID: 23552694; PMCID: PMC3667721

• He, F. and Ma, J. (2013). A spatial point pattern analysis in Drosophila blastoderm embryos evaluating the potential inheritance of transcriptional states.  PLoS ONE 8(4), e60876.  PMID: 23593336; PMCID: PMC3621909

• Liu, J. and Ma, J. (2013).  Uncovering a dynamic feature of the transcriptional regulatory network for anterior-posterior patterning in the Drosophila embryo. PLoS ONE 8(4), e62641.  PMID: 23646132; PMCID: PMC3639989

• Liu, J. and Ma, J.  (2013).  Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila.  Nature Communications 4, 2968.  PMID: 24336107; PMCID: PMC3902774

• Cheung, D., Miles, C., Kreitman, M., and Ma, J. (2014).  Adaptation of length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos.  Development 141, 122-135.  PMID: 24284208; PMCID: PMC3865754

• He, F., Wei, C., Wu, H., Cheung, D., Jiao, R., and Ma, J. (2015).  Fundamental origins and limits for scaling a maternal morphogen gradient.  Nature Communications 6, 6679.  PMID: 25809405; PMCID: PMC4375784 

• Cheung, D. and Ma, J. (2015).  Probing the impact of temperature on molecular events in a developmental system.  Scientific Reports 5, 13124.  PMID: 26286011; PMCID: PMC4541335

• Liu, J., and Ma, J. (2015).  Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo.   Development 142, 3781-3790. PMID: 26395487; PMCID: PMC4647213

• Wu, H., Manu, Jiao, R., and Ma, J. (2015).  Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila.  Nature Communications 6, 10031.  PMID: 26644070; PMCID: PMC4686680

• Liu, J., Xiao, Y., Zhang, T., and Ma, J. (2016).  Time to move on: Modeling transcription dynamics during an embryonic transition away from maternal control.  FLY (Austin) 10, 101-107.  PMID: 27172244

• Ma, J. (1998).  Book Review: Bartel, P. L. & Fields, S. (ed.) 1997; The Yeast Two-Hybrid System; Oxford University Press.  J. Eukaryotic Microbiol. 45, 333.  (Book review, no PMID or PMCID)

• Ma, J. (1998). Approaches for studying protein-protein interactions in vivo.  In: Applications of Molecular Biology Techniques. HaiNan Publishing House.  pp 35-67.  (Book chapter, no PMID or PMCID)

• Ma, J. (1999).  Promoter fusions to study gene expression.  In: Nature Encyclopedia of Life Sciences.  Nature Publishing Group, London, www.els.net.   (Encyclopedia article, no PMID or PMCID)

• Ma, J. (2000).  Yeast transcriptional activation and the two-hybrid system.  In: Yeast Hybrid Technologies, eds. L. Zhu and G. Hannon. BioTechniques Books/Eaton Publishing. pp 3-12.  (Book chapter, no PMID or PMCID) 

• Zhao, C., Dave, V., Fu, D., York, A., and Ma, J.  (2003).  Insights into the molecular functions of the Drosophila morphogenetic protein Bicoid.  Recent Res. Devel. Mol. Cell. Biol.  4, 115-126.  (Book chapter, no PMID or PMCID)

• Ma, J.  (2004).  Actively seeking activating sequences.  Cell S116, 75-76.  PMID: 15055589

• Ma, J. (2005).  Crossing the line between activation and repression.  Trends in Genetics 21, 54-59.  PMID: 15680515

• Ma, J. (2006).  Transcriptional activators and activation mechanisms. In: Gene Expression and Regulation (Ed. J. Ma), pp 147-158, Higher Education Press & Springer, Beijing-New York.  (Book chapter, no PMID or PMCID)

• Ma, J. (Ed.) (2006). Gene Expression and Regulation, A Current Scientific Frontiers Book, Higher Education Press & Springer, Beijing-New York.  (Book, no PMID or PMCID)

• Liu, J., He, F., and Ma, J. (2011).  Morphogen gradient formation and action: insights from studying Bicoid protein degradation.  FLY (Austin), 5, 242-246.  PMID: 21525787; PMCID: PMC3225767

• Ma, J. (2011).  Transcriptional activators and activation mechanisms.  Protein & Cell 2, 879-888.  PMID: 22180087; PMCID: PMC4712173

• Ma, J. (2014).  Promoter fusions to study gene expression (version 3.0).  In: eLS 2013 John Wiley & Sons Ltd: Chichester. http://www.els.net/ [doi: 10.1002/9780470015902.a0000976.pub3]. (Encyclopedia article, no PMID or PMCID)

• Gebelein, B. and Ma, J. (2016).  Regulation in the early Drosophila embryo.  Reviews in Cell Biology and Molecular Medicine 2, 140-167.  (Encyclopedia article, no PMID or PMCID)

• Ma, J., He, F., Xie., G., Deng, W.M. (2016).  Maternal AP determinants in the Drosophila oocyte and embryo.  WIREs Developmental Biology 5, 562-581.  PMID: 27253156

• 1989 – 1992      哈佛学会（Harvard Society of Fellows）青年会员

• 1983                  中美生物化学联合招生项目（CUSBEA）入选