PI介绍
个人简介
徐鹏飞,博士生导师,国家青年人才计划入选者,浙江省千人,浙江大学“百人计划”研究员。中国细胞生物学会“青年工作委员会”秘书长,中国生物医学工程学会“干细胞工程技术分会”委员,中国细胞生物学会“发育生物学分会”委员,中国动物学会“发育生物学分会”委员,中国动物学会“斑马鱼分会”青年委员,中国细胞生物学会“细胞工程和转基因生物分会”委员。
主要科研项目
1. 国家人才项目青年项目 300万
2. 国家自然科学基金 应急项目 15万 2018.01-2018.12
3. 国家自然科学基金 面上项目 57万 2020.01-2023.12
4. 国家自然科学基金 原创探索项目 300万 2021.01-2023.12
5. 科技部重点研发计划 “生殖健康及重大出生缺陷防控研究” 课题组组长 480万2018.12-2021.12
6. 科技部重点研发计划 “发育编程及其代谢调节” 课题骨干 105万 2020.01-2024.12
7. 科技部重点研发计划 “干细胞研究与器官修复” 课题组长 740万 2022.10-2027.12
代表性论文(#第一作者,*通讯作者)
1. Lin J#, Zhan G#, Liu J#, Maimaitiyiming Y, Deng Z, Li B, Su K, Chen J, Sun S, Zheng W, Yu X, He F, Cheng X, Wang L, Shen B, Yao Z, Yang X, Zhang J, He W, Wu H, Naranmandura H, Chang K-J, Min J, Ma J, Bjorklund M, Xu P-F*, Wang F*, Hsu C-H*, YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths, National Science Review, 2023-8;
2. Fu XX#, Zhuo DH#, Zhang YJ#, Li YF#, Liu X, Xing YY, Huang Y, Wang YF, Cheng T, Wang D, Chen SH, Chen YJ, Jiang GN, Lu FI, Feng Y, Huang X, Ma J, Liu W, Bai G*, Xu PF*. A spatiotemporal barrier formed by Follistatin is required for left-right patterning. PNAS. 2023 Jun
3. Cheng T#, Xing YY#, Liu C, Li YF, Huang Y, Liu X, Zhang YJ, Zhao GQ, Dong Y, Fu XX, Tian YM, Shu LP, Megason SG, Xu PF*. Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Reports. 2023 Apr;
4. Li YF#, Cheng T#, Zhang YJ, Fu XX, Mo J, Zhao GQ, Xue MG, Zhuo DH, Xing YY, Huang Y, Sun XZ, Wang D, Liu X, Dong Y, Zhu XS, He F, Ma J, Chen D, Jin X*, Xu PF*. Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biol. 2022 Nov;
5. Yi-Fan Wang#, Cong Liu#, Peng-Fei Xu*. Deciphering and reconstitution of positional information in the human brain development. Cell Regen 2021 Sep 1;
6. Peng-Fei Xu#, Ricardo Moraes Borges#, Jonathan Fillatre#, Maraysa de Oliveira-Melo, Tao Cheng, Bernard Thisse & Christine Thisse*. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nat Commun. 2021, 12;
7. Ying Huang#, Shan-He Yu#, Wen-Xuan Zhen, Tao Cheng, Dan Wang, Jie-Bo Lin, Yu-Han Wu, Yi-Fan Wang, Yi Chen, Li-Ping Shu, Yi Wang, Xiao-Jian Sun, Yi Zhou, Fan Yang*, Chih-Hung Hsu*, Peng-Fei Xu*. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 2021, Vol. 11, Issue 14;
8. Yu SH, Zhu KY, Zhang F, Wang J, Yuan H, Chen Y, Jin Y, Dong M, Wang L, Jia XE, Gao L, Dong ZW, Ren CG, Chen LT, Huang QH, Deng M, Zon LI, Zhou Y, Zhu J*, Xu PF*, Liu TX. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta. 2018 Jan 26;
9. Du TT#, Xu PF#, Dong ZW, Fan HB, Jin Y, Dong M, Chen Y, Pan WJ, Ren RB, Liu TX, Deng M, Huang QH*. Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev Biol. 2014 Jun;
10. Peng-Fei Xu#, Nathalie Houssin#, Karine F. Ferri-Lagneau#, Bernard Thisse, Christine Thisse*. Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients. Science 2014, April;
11. Peng-Fei Xu, Kang-Yong Zhu, Yi Jin, Yi Chen, Xiao-Jian Sun, Min Deng, Sai-Juan Chen, Zhu Chen, and Ting-Xi Liu*. Setdb2 restricts dorsal organizer territory and regulates left–right asymmetry through suppressing fgf8 activity, PNAS. 2010, January;
12. Xiao-Jian Sun#, Peng-Fei Xu#, Ting Zhou, Ming Hu, Chun-Tang Fu, Yong Zhang, Yi Jin, Yi Chen, Sai-Juan Chen, Qiu-Hua Huang, Ting Xi Liu*, Zhu Chen*. Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS ONE 2008, January.
代表性著作
1.《医学遗传学》高等教育出版社,编委
获奖
1. 贵州省自然科学奖二等奖(排名第三)2022年
2. 浙江大学校先进工作者,2020
3. 浙江大学医学院先进工作者,2020
4. 浙江大学医学院先进工作者,2018
5. 中组部 “千人计划青年项目”,2017
6. 最佳博士后报告,Mid-Atlantic Regional Society of Developmental Biology Meeting, 2013年
7. 上海市优秀毕业论文, 2010年
8. 瑞金医院博士后研究之星, 2009年
9. 上海交通大学优秀毕业生, 2009年