PI介绍
邹朝春
（ 主任医师 ）
导师类型：博士生导师（儿科学和遗传学）
专业：儿科学，内分泌代谢和遗传学
邮箱地址：zcc14@zju.edu.cn
研究方向：
内分泌代谢相关疾病的临床和基础研究；遗传（罕见）病，尤其发育相关遗传病和表观遗传病的机制及临床转化。
个人简介
邹朝春，医学博士，博士生导师；浙江省医疗卫生领军人才、浙江省新世纪151人才。
浙江大学医学院附属儿童医院主任医师，从事儿童内分泌代谢和遗传病的临床、科研和教学工作30余年。主持和参与各类科研项目20余项，包括主持国家自然科学基金3项、浙江省重点研发项目1项、浙江省自然科学基金杰青1项、省部共建项目2项。发表论文200余篇，发表第一或通讯作者的SCI收录的论文70余篇；已获得浙江省人民政府科学技术奖二等奖3项。中华医学会罕见病分会委员和儿科学分会罕见病学组副组长、中华预防医学会儿童保健学分会常委、中国医师协会毕业后医学教育儿科专业委员会副主任委员和毕业后医学教育评估专业委员会副主任委员、全国科学技术名词审定委员会儿科学名词编写委员会副主编。
主要科研项目
1. 国家卫健委科学研究基金-浙江省卫生健康重大科研计划项目（重大项目）. 黏多糖贮积症诊断和分型技术研发（WKJ-ZJ-2409）. 2024.1-2027.12, 50万, 在研，项目负责人
2. 浙江省重点研发计划项目.儿童疾病诊治新技术研究-Prader-Willi综合征诊断新技术建立和临床研究(2021C03094)，2021.1-2024.12, 270万，已结题，项目负责人
3. 北海康成（上海）生物科技有限公司（香港）. 一项浙江地区黏多糖II型（MPSII）患者登记研究—基于自然病史和高危因素的患者筛查和确诊。 2021.1-2021.12，50万，已结题，项目负责人
4. 国家自然科学基金（面上项目），Sonic hedgehog信号通路在胎盘滋养层11β-HSD2表达调控中的效应和机制研究（81670786），2017.1-2020.12，69.6万，已结题，项目负责人
5. 国家自然科学基金（面上项目），基于NIPBL基因剔除致Cornelia de Lange综合征的认知障碍机制研究（81371215），2014.1-2017.12，70万，已结题，项目负责人
6. 国家自然科学基金（面上项目），胎盘II型11β-羟基类固醇脱氢酶调控胎源性成年代谢综合征研究（81170787），国家自然科学基金，2012.1-2015.12，58万，已结题，项目负责人
7. 浙江省自然科学基金杰出青年基金（LR13H090002），NIPBL基因在Cornelia de Lange 综合征认知障碍中的作用和机制研究. 2013.1-2016.12，30万，已结题，项目负责人
8. 浙江省重点科技创新团队（儿童出生缺陷早期筛查与干预技术创新团队）自主立项项目，I和II型11β-羟基类固醇脱氢酶基因多态性与儿童代谢综合征的相关性研究（2010R50045-7）. 2011.4-2014.3，10万，已结题，项目负责人
9. 卫生部和浙江省卫生厅省部共建项目，脂联素基因组蛋白乙酰化在肥胖发生机制中的作用（WKJ2011-2-008）. 2011.6-2013.6, 15万，已结题，项目负责人
10. 浙江省科技厅重大课题，青少年肥胖、代谢综合征综合防治平台的建设(2008C03002-1)，2008.9-2011.12，70万. 已结题，第2参与人
代表性论文（#第一作者，*通讯作者）
1. Mao S#, Yang L#, Gao Y, Zou C*. Genotype-phenotype correlation in Prader-Willi syndrome: A large-sample analysis in China. Clin Genet. 2024;105(4):415-422.
2. Gu R#, Wang H#, Wang CL, Lu M, Miao M, Huang MN, Chen Y, Dai YL, Zhu MQ, Zhou Q, Zou CC*. Gene variants and clinical characteristics of children with sitosterolemia. Lipids Health Dis. 2024;23(1):83.
3. Zhong ML, Cai YQ, Tang YF, Dai YL, Jiang YH, Ni Y*, Zou CC*. Gut microbiota, a potential cause of higher insulin sensitivity in children with Prader-Willi syndrome. J Endocrinol Invest. 2024 Apr;47(4):1029-1036.
4. Li JW, Mao SJ, Chao YQ, Hu CX, Qian YJ, Dai YL, Huang K, Shen Z, Zou CC*. Application of tandem mass spectrometry in the screening and diagnosis of mucopolysaccharidoses. Orphanet J Rare Dis. 2024;19(1):179.
5. Miao M#, Zhao GQ#, Zhou Q, Chao YQ, Zou CC*. Orthopedic manifestations in children with Prader-Willi syndrome. BMC Pediatr. 2024 Feb 14; 24(1):118.
6. Gao Y#, Yang LL#, Dai YL, Shen Z, Zhou Q*, Zou CC*. Effects of early recombinant human growth hormone treatment in young Chinese children with Prader-Willi syndrome. Orphanet J Rare Dis 2023; 18:25.
7. Chen W, Sun L, He X, Li Z, Ji C, Li F, Shen J, Pan T, Jin X, Dong Y, Hu L, Zou C*, Bai G*. Health-related quality of life of children with Williams syndrome and caregivers in China. Front Public Health. 2023; 11:1177317.
8. Sun JR, Yang LZ, Dai YL, Wu H, Li S, Xu YF, Huang Y, Wu H, Shen Z, Zou C*, Chen LL*. Using sno-lncRNAs as potential markers for Prader-Willi syndrome diagnosis. RNA Biol. 2023; 20(1):419-430.
9. Qian Y, Xia F, Zuo Y, Zhong M, Yang L, Jiang Y, Zou C*. Do patients with Prader-Willi syndrome have favorable glucose metabolism? Orphanet J Rare Dis. 2022; 17(1):187.
10. Shu Y, Zou C*, Cai Y, He Q, Wu X, Zhu H, Qv M, Chao Y, Xu C, Tang L, Wu X*. Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β. Redox Biol. 2022; 56:102420.
11. Chao Y, Gao L, Wang X, Cai Y, Shu Y, Zou X, Qin Y, Hu C, Dai Y, Zhu M, Shen Z, Zou C*. Dysregulated adipose tissue expansion and impaired adipogenesis in Prader-Willi syndrome children before obesity-onset. Metabolism. 2022; 136:155295.
12. Chao Y, Qin Y, Zou X, Wang X, Hu C, Xia F, Zou C*. Promising therapeutic aspects in human genetic imprinting disorders. Clin Epigenetics. 2022;14(1):146.
13. Chao Y, Jiang Y, Zhong M, Wei K, Hu C, Qin Y, Zuo Y, Yang L, Shen Z, Zou C*. Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health. Cell Biosci. 2021;11(1):66.
14. Yang L, Zhou Q, Ma B, Mao S, Dai Y, Zhu M, Zou C*. Perinatal features of Prader-Willi syndrome: a Chinese cohort of 134 patients. Orphanet J Rare Dis. 2020;15(1):24-29.
15. Mian-Ling Z, Yun-Qi C, Chao-Chun Z*. Prader-Willi syndrome: molecular mechanism and epigenetic therapy. Curr Gene Ther 2020; 20(1):36-43.
16. Yang L, Ma B, Mao S, Zhou Q, Zou C*. Establishing perinatal and neonatal features of Prader-Willi syndrome for efficient diagnosis and outcomes. Expert Opinion on Orphan Drugs 2020, 8(8):265-271.
17. Mao SJ, Shen J, Xu F, Zou CC*. Quality of life in caregivers of young children with Prader-Willi syndrome. World J Pediatr. 2019;15(5):506-510.
18. Qing Z, Xiao-Hui W, Xi-Mei W, Chao-Chun Z*. Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance. Eur J Pharmacol. 2018; 829:1-11.
19. Bo L, Yi-Can Y, Qing Z, Xiao-Hui W, Ke H, Chao-Chun Z*. Elevated tumour necrosis factor-alpha was associated with intima thickening in obese children. Acta Paediatr. 2017 Apr;106(4):627-633.
20. Shi JQ, Shen WX, Wang XZ, Huang K, Zou CC*. Relationship between immune parameters and non-alcoholic fatty liver disease in obese children. Indian Pediatr 2017 Jul 11. 2017, 54(10) :825-829.
21. Tang C, Tang L, Wu X, Xiong W, Ruan H, Hussain M, Wu J, Zou C*, Wu X*. Glioma-associated oncogene-2 is essential for trophoblastic fusion by forming a transcriptional complex with Glial cell missing-a. J Biol Chem. 2016 Mar 11; 291(11):5611-22.
22. Zhu H#, Zou C#, Fan X, Xiong W, Tang L, Wu X, Tang C. Upregulation of 11β-hydroxysteroid dehydrogenase type 2 expression by Hedgehog ligand contributes to the conversion of cortisol into cortisone. Endocrinology. 2016 Sep;157(9):3529-39.
23. Ruan LL, Xu J, Wang CL, Zou CC*. Variants of 11β-hydroxysteroid dehydrogenase (HSD11B) gene type 1 and 2 in Chinese obese adolescents. J Endocrinol Invest 2014 Jun; 37(6):565-73.
24. Zou CC, Chen XY, Zhao ZY, Zhang WF, Shu Q, Wang JH, Zhang L, Huang SJ, Yang LL. Outcome of children with melamine-induced urolithiasis: results of a two-year follow-up. Clin Toxicol (Phila) 2013 Jul;51(6):473-9.
25. Zou CC, Zhao ZY, Liang L. Childhood minimally invasive follicular carcinoma: clinical features and immunohistochemistry analysis. J Paediatr Child Health 2010; 46(4) 166-170.
26. Zou CC, Chen X, Liang L, Zhao ZY. Childhood combined pituitary hormone deficiency a five-year retrospective study. Endocrinologist 2010;20(3):125-127.
27. Huang XY, Tang LF, Zou CC*, Zhao ZY. Chromosome analysis in 8158 pediatric patients: an experiment of 29 years from Hangzhou, China. Endocrinologist 2010; 20(4): 179-181.
28. Zou CC, Liang L, Wang CL, Fu JF, Zhao ZY. The change in ghrelin and obestatin levels in obese children after weight reduction. Acta Paediatrica 2009 Jan;98(1):159-65.
29. Zhang L, Wu LL, Wang YP, Liu AM, Zou CC*, Zhao ZY. Melamine-contaminated milk products induced urinary tract calculi in children. World J Pediatr 2009; 5(1): 31-35.
30. Zou CC, Zhao ZY, Liang L. Childhood Kikuchi-Fujimoto disease. Indian J Pediatr 2009; 76(9):959-62.
31. Zou CC, Huang K, Liang L Zhao ZY. Polymorphisms of the ghrelin/obestatin gene and ghrelin levels in Chinese children with short stature. Clin Endocrinol (Oxf). 2008 Jan 8; 69 (1):99-104.
32. Zou CC, Liang L, Hong F, Zhao ZY. Glucose metabolism disorder in obese children assessed by continuous glucose monitoring system. World J Pediatr 2008; 4(1): 26-30.
33. Gu WZ, Zou CC*, Zhao ZY, Liang L, Tang HF. Childhood pancreatoblastoma: clinical features and immunohistochemistry analysis. Cancer Lett 2008 Feb 26; 264(1): 119-126.
34. Zou CC, Liang L, Dong GP, Zhao ZY. Peripheral precocious puberty: A retrospective study for six years in Hangzhou, China. J Paediatr Child Health. 2008 Jun 18; 44(7): 415-8.
35. Yu ZS, Tang LF, Zou CC*, Zheng JY, Zhao ZY. Cytomegalovirus-associated idiopathic thrombocytopenic purpura in Chinese children. Scand J Infect Dis 2008; 40: 922-927.
36. Zou CC, Liang L, Hong F. Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity. Indian Pediatr 2007 April 17; 44(4):275-279.
37. Wu F, Zou CC*. Childhood Weber-Christian disease: clinical investigation and virus detection. Acta Paediatrica 2007 Sep 21; 96(11): 1665-1669
38. Zou CC, Zhao ZY. Clinical and molecular analysis of NF-kappaB essential modulator in Chinese incontinentia pigmenti patients. Int J Dermatol 2007 Oct; 46(10): 1017-22.
39. Zou CC, Zhao ZY, Tang LF, Liang L. Plasma levels of matrix metalloproteinase-9 in Henoch-Schönlein purpura. Scand J Rheumatol 2006 Jan-Feb;35(1):52-5.
40. YU ZS, Zou CC*, Zhen JY, Zhao ZY. Cytomegalovirus gB genotype and clinical feature in Chinese infants with congenital infection. Intervirology 2006 May 22;49(5):281-285.
41. Zou CC, Liang L. Multiple hypoechoic lesions in spleen and Mycoplasma Pneumoniae infection. Indian Pediatr. 2005 Apr; 42(4):379-382.
42. Zou CC, Liang L, Hong F, Fu JF, Zhao ZY. Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children. Endocrin J 2005 Oct;52(5):519-24.
43. Zou CC, Zhao ZY, Tang LM, Chen ZM, Du LZ. The effects of lead on brainstem auditory evoked potentials in children. Chin Med J 2003 Apr;116(4): 565-568.
44. Zou C, Tsukahara H, Hiraoka M, Mizu J, Todoroki Y, Ohshima Y, Kimura H, Tsuzuki K, Mayumi M. Methylenetetrahydrofolate reductase (MTHFR) polymorphism in childhood primary focal segmental glomerulosclerosis. Nephron 2002 Oct; 92(2):449-451
45. 邹朝春, 梁黎, 傅君芬, 吕兰秋, 留佩宁, 黄轲, 王春林. 肥胖儿童及青少年脂代谢紊乱与早期心血管病变的关系. 中华儿科杂志 2010; 48(6):413-417.
46. 戴阳丽, 邹朝春*. Prader-Willi综合征诊治进展. 中华儿科杂志, 2023, 61(2): 190-192.
代表性著作
1. 王艺主编，邹朝春、蒋莉，张月华，金润铭副主编. 十四五时期国家重点出版物出版专项规划项目，儿科疾病诊疗规范丛书—儿童罕见病诊疗规范. 人民卫生出版社，北京. 2023.12. ISBN 978-7-117-35739-5
2. 赵正言，周文浩，梁德生主编，邹朝春等副主编. 新生儿基因筛查. 人民卫生出版社. 北京，2022-11. ISBN：978-7-117-33643-7.
3. 赵正言等主编，邹朝春副主编. 儿童保健学. 第五版. 凤凰出版社. 南京. 2017年2月. ISBN: 9787553741369
4. 孙锟，赵正言，王天有. 中国科学院教材建设专家委员会规划教材 医学英文原版改编双语教材. (Rudolph’s Pediatrics, 22nd Edition) TEXTBOOK OF PEDIATRICS 儿科学(英文改编版) 第 2 版. 科学出版社. 2021.3 北京. ISBN: 978-0-07-174684-7
5. 丁洁主编，邹朝春等编委. 中国《第一批罕见病目录》罕见病诊疗费用调研. 2021.4出版
6. 丁洁、王琳主编，邹朝春编委. 121种罕见病知识读本. 中国健康传媒集团中国医药科技出版社. 北京. 2019.1, 第一版, ISBN: 978-7-5214-0731-0.
7. 赵正言主编，邹朝春编委. 儿科疾病临床诊断标准解读. 人民卫生出版社. 北京. 第1版. 201804. ISBN: 9787117259972.
8. 桂永浩, 毛萌主译, 杜立中, 罗小平副主译, 邹朝春译者. 尼尔逊儿科学(Nelson Textbook of Pediatrics)第19版. 人民卫生出版社. 2017年9月. ISBN：9787519204648
9. 申昆玲主译, 刘翰旻, 许志飞, 张爱华, 赵晓东, 邹朝春副主译. 儿科感染性疾病临床手册第29版(Red Book, AAP, 2012, 29th). 人民卫生出版社. 北京. 2016年2月第一版. ISBN 978-7-117-21049-2/R·21050
10. 申昆玲主编. 邹朝春编委. 国家卫计委“健康中国行—全民健康素养促进活动”推荐用书. 儿童就医指导. 第一版. 人民卫生出版社. 2015.4.
共识指南制定
1. 牵头. Recommendations for the diagnosis and management of childhood Prader‑Willi syndrome in China. Orphanet J Rare Dis 2022; 17:221.
2. 参与. Application of next generation sequencing in the screening of monogenic diseases in China, 2021: a consensus among Chinese newborn screening experts. World J Pediatr. 2022 Apr;18(4):235-242.
3. 牵头. 儿童脂质异常血症诊治专家共识（2022）[J]. 中华儿科杂志, 2022, 60(7): 633-639.
4. 牵头. 中国儿童Bardet-Biedl综合征诊治专家共识. 中国实用儿科杂志 2022; 37(4):241-247.
5. 参与. 中国黏多糖贮积症Ⅱ型临床诊疗专家共识. 中华儿科杂志. 2021. 59(6):446-451.
6. 参与. 儿童X连锁低磷性佝偻病诊治与管理专家共识. 中华儿科杂志2022; 60(6):501-506.
7. 参与. 中国儿童健康体检专家共识. 中国实用儿科杂志 2022; 37(8):561-566, 574
8. 参与.黏多糖贮积症I型诊疗专家共识（2022）. 中华儿科杂志 2023: 61(3)：204-209.)
9. 参与. 中国新生儿基因筛查专家共识：高通量测序在单基因病筛查中的应用. 中华实用儿科临床杂志, 2023,38(1):31-36.
10. 参与. 儿童低促性腺激素性性腺功能减退症诊治专家共识. 中华儿科杂志. 2023; 61(6): 484-490.
11. 参与. 基于体卫融合的儿童青少年运动指南. 中华行为医学与脑科学杂志 2024; 33(8): 673-685.
